The series follows the rise of the Borgia family to the peak of the Roman Catholic Church. We also see their struggles to maintain their grip on the power they wield.
Newly appointed Cardinal Farnese, promoted at the request of his sister Giulia, is placed in the Treasury and quickly discovers Versucci’s theft. Micheletto is sent to find the wayward Cardinal.
Meanwhile, upon hearing of Venice’s request for help against Turkish pirates, Alexander, seeing this as an opportunity to replenish the coffers, dramatically calls for a Crusade.